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Didanosine
CAS No. 69655-05-6
Didanosine ( NSC 612049 )
Catalog No. M15668 CAS No. 69655-05-6
Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 31 | In Stock |
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| 10MG | 50 | In Stock |
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| 25MG | 77 | In Stock |
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| 50MG | 102 | In Stock |
|
| 100MG | 151 | In Stock |
|
| 200MG | 224 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDidanosine
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NoteResearch use only, not for human use.
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Brief DescriptionDidanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
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DescriptionDidanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.(In Vitro):Didanosine is converted by cellular enzymes to the active antiviral metabolite dideoxyadenosine triphosphate (dd-ATP) and the intracellular half life of dd-ATP varies from 8-24 hours.Didanosine shows antiretroviral activity with IC50 value of 0.24-0.6 mg/L for HIV infection.Didanosine (5, 10, 50, 100 ug/ml; 24, 48 h) shows no significant inhibition of cell proliferation in IEC-6 cells.(In Vivo):Didanosine (100, 150 mg/kg; p.o.; daily for 7 days) decreases the length of duodenal and in jejunal villus in mouse.
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In VitroDidanosine is converted by cellular enzymes to the active antiviral metabolite dideoxyadenosine triphosphate (dd-ATP) and the intracellular half life of dd-ATP varies from 8-24 hours.Didanosine shows antiretroviral activity with IC50 value of 0.24-0.6 mg/L for HIV infection.Didanosine (5, 10, 50, 100 ug/ml; 24, 48 h) shows no significant inhibition of cell proliferation in IEC-6 cells. Cell Proliferation Assay Cell Line:IEC-6 cells Concentration:5, 10, 50, 100 ug/ml Incubation Time:24, 48 h Result:Did not show any significant inhibition of cell proliferation at either 24 h or 48 h.Apoptosis Analysis Cell Line:IEC-6 cells Concentration:100 ug/ml Incubation Time:24 h Result:Induced apoptosis with the apoptosis rates of 4.7% to 7.4%.
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In VivoDidanosine (100, 150 mg/kg; p.o.; daily for 7 days) decreases the length of duodenal and in jejunal villus in mouse. Animal Model:30-40 g, male swiss mice Dosage:100, 150 mg/kg Administration:P.o.; daily for 7 days Result:Caused significant reductions in duodenal and in jejunal villus length and significantly decreased ileal crypt depth.
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SynonymsNSC 612049
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PathwayMicrobiology/Virology
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TargetReverse Transcriptase
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RecptorReverse Transcriptase
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number69655-05-6
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Formula Weight236.23
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Molecular FormulaC10H12N4O3
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Purity>98% (HPLC)
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SolubilityDMSO: 47 mg/mL (198.95 mM)
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SMILESC1C[C@@H](O[C@@H]1CO)N2C=NC3=C2NC=NC3=O
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Chemical Name9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Benbrik E, et al. J Neurol Sci, 1997, 149(1), 19-25.
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