Stavudine

Research use only, not for human use.

Stavudine is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

Stavudine is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.(In Vitro):Stavudine (d4T) (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages.Stavudine (d4T) (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages.Stavudine (d4T) (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels.(In Vivo):Stavudine (d4T) (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice.

Stavudine (d4T) (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages.Stavudine (d4T) (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages.Stavudine (d4T) (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels.

Stavudine (d4T) (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice. Animal Model:Male RjOrl Swiss mice weighing 0.028-0.03 kg Dosage:500 mg/kg Administration:Daily liquid; 2 weeks Result:Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group.Significantly elevated plasma ALT and LDH levels.Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels.Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg.

d4T | NSC 163661

Microbiology/Virology

Reverse Transcriptase

Reverse Transcriptase

Infection

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3056-17-5

224.21

C10H12N2O4

>98% (HPLC)

Ethanol: 15 mg/mL (66.9 mM); DMSO: 45 mg/mL (200.7 mM)

OC[C@@H]1C=C[C@H](N2C(NC(C(C)=C2)=O)=O)O1

1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

(-20℃)

With Ice Pack

≥ 2 years