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TDZD-8
CAS No. 327036-89-5
TDZD-8( TDZD 8 | TDZD8 | GSK-3β Inhibitor I | NP 01139 )
Catalog No. M14061 CAS No. 327036-89-5
A potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 38 | In Stock |
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| 10MG | 48 | In Stock |
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| 25MG | 69 | In Stock |
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| 50MG | 113 | In Stock |
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| 100MG | 178 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTDZD-8
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM).
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DescriptionA potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM); reduces the colonic inflammation induced by TNBS in vivo, also prevents 6-OHDA-induced neuronal cell death.
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In Vitro——
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In Vivo——
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SynonymsTDZD 8 | TDZD8 | GSK-3β Inhibitor I | NP 01139
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3β
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number327036-89-5
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Formula Weight222.2636
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Molecular FormulaC10H10N2O2S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N1CC2=CC=CC=C2)N(C)SC1=O
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Chemical Name1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Martinez A, et al. J Med Chem. 2002 Mar 14;45(6):1292-9.
2. Whittle BJ, et al. Br J Pharmacol. 2006 Mar;147(5):575-82.
3. Dugo L, et al. Crit Care Med. 2005 Sep;33(9):1903-12.
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