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Ansamitocin P-3

CAS No. 66547-09-9

Ansamitocin P-3( Maytansinol butyrate )

Catalog No. M15536 CAS No. 66547-09-9

A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 61 In Stock
2MG 28 In Stock
5MG 44 In Stock
10MG 72 In Stock
25MG 141 In Stock
50MG 224 In Stock
100MG 333 In Stock
200MG 462 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Ansamitocin P-3
  • Note
    Research use only, not for human use.
  • Brief Description
    A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM).
  • Description
    A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation; inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Maytansinol butyrate
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADC Cytotoxin
  • Recptor
    microtubule
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    66547-09-9
  • Formula Weight
    635.1448
  • Molecular Formula
    C32H43ClN2O9
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O
  • Chemical Name
    Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ootsu K, et al. Cancer Res. 1980 May;40(5):1707-17. 2. Venghateri JB, et al. PLoS One. 2013 Oct 4;8(10):e75182. 3. Martin K, et al. Cancer Immunol Immunother. 2014 Sep;63(9):925-38.
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