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Maytansinol
CAS No. 57103-68-1
Maytansinol( Ansamitocin P-0 )
Catalog No. M15080 CAS No. 57103-68-1
Maytansinol (Ansamitocin P-0) is a microtubule assembly inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | Get Quote |
|
| 5MG | 86 | Get Quote |
|
| 10MG | 146 | Get Quote |
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| 25MG | 264 | Get Quote |
|
| 50MG | 443 | Get Quote |
|
| 100MG | 619 | Get Quote |
|
| 200MG | 878 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMaytansinol
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NoteResearch use only, not for human use.
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Brief DescriptionMaytansinol (Ansamitocin P-0) is a microtubule assembly inhibitor.
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DescriptionMaytansinol (Ansamitocin P-0) is a microtubule assembly inhibitor; ADC payload in development of antibody drug conjugates.
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In VitroCell Viability Assay Cell Line:HCT116 Concentration:0.09, 0.13, 0.18, 0.26, 0.37, 0.53, 0.75 nM Incubation Time:24 h Result:Reduced the growth and survival of HCT116 cells in a dose-dependent manner and the effect was more severe for p53+/+ than for p53–/– cells at both low and high doses. At intermediate doses, the effect was not significantly different on wild-type and p53 mutant cells.
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In Vivo——
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SynonymsAnsamitocin P-0
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PathwayAntibody Drug Conjugates (ADC)
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TargetADC Cytotoxin
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RecptorADC Cytotoxin
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number57103-68-1
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Formula Weight565.055
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Molecular FormulaC28H37ClN2O8
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 35 mg/mL
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SMILESO=C1O[C@@]([C@@H](C)[C@H]2[C@](C)([C@@H](O)CC3=O)O2)([H])C[C@@]([C@H](OC)/C=C/C=C(CC4=CC(OC)=C(Cl)C(N3C)=C4)\C)(O)N1
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Chemical NameMaytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Higashide E, et al. Nature. 1977 Dec 22-29;270(5639):721-2.
2. Barginear MF, et al. Mol Med. 2013 Jan 22;18:1473-9.
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