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TGX-221
CAS No. 663619-89-4
TGX-221( TGX221 | TGX 221 )
Catalog No. M15529 CAS No. 663619-89-4
A potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 106 | In Stock |
|
| 25MG | 206 | In Stock |
|
| 50MG | 340 | In Stock |
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| 100MG | 530 | In Stock |
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| 500MG | 1134 | In Stock |
|
| 1G | Get Quote | In Stock |
|
| 1 mL x 10 mM in DMSO | 57 | In Stock |
|
| 2MG | 33 | In Stock |
|
| 5MG | 52 | In Stock |
|
| 10MG | 90 | In Stock |
|
| 25MG | 186 | In Stock |
|
| 50MG | 300 | In Stock |
|
| 100MG | 454 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTGX-221
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.
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DescriptionA potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM; weakly inhibits p110δ (IC50=211 nM), and no activity against p110α (IC50>1 uM); inhibits platelet-ECC interaction, platelet aggregation and platelet-granulocyte binding; shows anti-thrombotic effectt devoid of other cardiovascular actions in rats.
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In Vitro——
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In Vivo——
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SynonymsTGX221 | TGX 221
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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Recptorp110α|p110β|p110γ|p110δ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number663619-89-4
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Formula Weight364.4409
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Molecular FormulaC21H24N4O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1C=C(N2CCOCC2)N=C3N1C=C(C)C=C3C(NC4=CC=CC=C4)C
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Chemical Name4H-Pyrido[1,2-a]pyrimidin-4-one, 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Frazzetto M, et al. Biochem J. 2008 Sep 15;414(3):383-90.
2. Sturgeon SA, et al. Eur J Pharmacol. 2008 Jun 10;587(1-3):209-15.
3. Chaussade C, et al. Biochem J. 2007 Jun 15;404(3):449-58.
4. Straub A, et al. Thromb Haemost. 2008 Mar;99(3):609-15.
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