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Asenapine

CAS No. 65576-45-6

Asenapine( Org 5222 | Org-5222 | Org5222 )

Catalog No. M15492 CAS No. 65576-45-6

A potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 76 In Stock
5MG 68 In Stock
10MG 93 In Stock
25MG 160 In Stock
50MG 230 In Stock
100MG 339 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Asenapine
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors.
  • Description
    A potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors; shows much lower affinity (pKi<5) for muscarinic receptor; behaves as a potent antagonist 5-HT receptors (5-HT2A pKB=9.0), dopaime and adrenoceptors; shows strong antipsychotic potential in vivo.Schizophrenia Approved.
  • In Vitro
    ——
  • In Vivo
    Asenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy. Animal Model:Adult male Wistar rats (200-250 g) Dosage:0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg Administration:Subcutaneous injection Result:Produced suppression of CAR in a dose-dependent manner.
  • Synonyms
    Org 5222 | Org-5222 | Org5222
  • Pathway
    GPCR/G Protein
  • Target
    Adrenergic Receptor
  • Recptor
    Adrenergic Receptor
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    65576-45-6
  • Formula Weight
    285.768
  • Molecular Formula
    C17H16ClNO
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24
  • Chemical Name
    1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aR,12bR)-rel-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Room P, et al. Eur J Pharmacol. 1991 Dec 3;205(3):233-40. 2. Broekkamp CL, et al. Arzneimittelforschung. 1990 May;40(5):544-9. 3. Fr?nberg O, et al. Psychopharmacology (Berl). 2008 Feb;196(3):417-29. 4. Shahid M, et al. J Psychopharmacol. 2009 Jan;23(1):65-73.
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