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Asenapine
CAS No. 65576-45-6
Asenapine( Org 5222 | Org-5222 | Org5222 )
Catalog No. M15492 CAS No. 65576-45-6
A potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 76 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 160 | In Stock |
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| 50MG | 230 | In Stock |
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| 100MG | 339 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAsenapine
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NoteResearch use only, not for human use.
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Brief DescriptionA potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors.
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DescriptionA potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors; shows much lower affinity (pKi<5) for muscarinic receptor; behaves as a potent antagonist 5-HT receptors (5-HT2A pKB=9.0), dopaime and adrenoceptors; shows strong antipsychotic potential in vivo.Schizophrenia Approved.
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In Vitro——
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In VivoAsenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy. Animal Model:Adult male Wistar rats (200-250 g) Dosage:0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg Administration:Subcutaneous injection Result:Produced suppression of CAR in a dose-dependent manner.
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SynonymsOrg 5222 | Org-5222 | Org5222
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PathwayGPCR/G Protein
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number65576-45-6
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Formula Weight285.768
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Molecular FormulaC17H16ClNO
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24
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Chemical Name1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aR,12bR)-rel-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Room P, et al. Eur J Pharmacol. 1991 Dec 3;205(3):233-40.
2. Broekkamp CL, et al. Arzneimittelforschung. 1990 May;40(5):544-9.
3. Fr?nberg O, et al. Psychopharmacology (Berl). 2008 Feb;196(3):417-29.
4. Shahid M, et al. J Psychopharmacol. 2009 Jan;23(1):65-73.
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