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PptT inhibitor 8918
CAS No. 65009-19-0
PptT inhibitor 8918( Compound 8918 )
Catalog No. M15469 CAS No. 65009-19-0
PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePptT inhibitor 8918
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NoteResearch use only, not for human use.
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Brief DescriptionPptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM).
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DescriptionPptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv; also exhibits MIC90s ranged from 0.56-3.0 uM (median 1.5 uM) against 29 clinical isolates of Mtb; inhibits growth of WT Mtb, but not of the pptT mutant W170S or WT Mtb expressing the pptT W170S mutant; kills Mycobacterium tuberculosis (Mtb) by binding and partially inhibiting PptT.
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In Vitro——
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In Vivo——
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SynonymsCompound 8918
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number65009-19-0
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Formula Weight262.357
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Molecular FormulaC14H22N4O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameAmidino-urea 1-[(2,6-diethylphenyl)-3-N-ethylcarbamimodoyl]urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ballinger E, et al. Science. 2019 Feb 1;363(6426). pii: eaau8959. doi: 10.1126/science.aau8959.
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