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ABMA
CAS No. 332108-65-3
ABMA( —— )
Catalog No. M14116 CAS No. 332108-65-3
ABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 44 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 112 | In Stock |
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| 50MG | 174 | In Stock |
|
| 100MG | 266 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 586 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameABMA
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NoteResearch use only, not for human use.
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Brief DescriptionABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite.
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DescriptionABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite; protects mice from nasal instillation of an LD90 of ricin; provokes Rab7-positive late endosomal compartment accumulation in mammalian cells without affecting other organelles.
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In VitroABMA protects cells against four bacterial toxins (Corynebacterium diphtheriae (DT; EC50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC50 of 73.3μM), Clostridium sordellii lethal toxin (TcsL; EC50 of 86.7 μM)), three viruses (Ebola (EC50 of 3.3μM), rabies (EC50 of 19.4μM), dengue-4 virus ( EC50 of 8.2?μM)), two species of Chlamydiales intracellular bacteria (Simkania negevensis and Chlamydia trachomatis), and the parasite Leishmania infantum (EC50 of 7.1μM) at micromolar level.In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC50 of 3.8?μM, and a protection factor (R) at 30?μM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days.
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In VivoAnimal Model:Pathogen-free female BALB/c mice (6 week-old) with ricin Dosage:2 mg/kg, 20 mg/kg, 200 mg/kg Administration:Intraperitoneal injection Result:A statistically significant protection according to survival curves was observed with a single ip dose of 2?mg/kg. The 20?mg/kg dose fully protected animals through to day 21. The 200?mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.
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Synonyms——
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number332108-65-3
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Formula Weight350.3
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Molecular FormulaC18H24BrNO
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (356.85 mM)
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SMILES——
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Chemical Name1-adamantyl (5-bromo-2-methoxybenzyl) amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wu Y, et al. Sci Rep. 2017 Nov 14;7(1):15567.
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