Cart
sales@molnova.com
Amodiaquine hydrochloride
CAS No. 6398-98-7
Amodiaquine hydrochloride( —— )
Catalog No. M15431 CAS No. 6398-98-7
A 4-aminoquinoline compound with anti-inflammatory properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 34 | In Stock |
|
| 100MG | 31 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 69 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAmodiaquine hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionA 4-aminoquinoline compound with anti-inflammatory properties.
-
DescriptionA 4-aminoquinoline compound with anti-inflammatory properties. (In Vitro):Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.(In Vivo):Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.
-
In VitroAmodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells. RT-PCR Cell Line:Primary microglia Concentration:10 μM, 15 μM, 20 μM Incubation Time:4 hours Result:Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
-
In VivoAmodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice. Animal Model:Male ICR mice (8-10?weeks of age) induced ntracerebral hemorrhage (ICH) Dosage:40 mg/kg Administration:Intraperitoneal injection; daily; for 3 days Result:Diminished perihematomal activation of microglia/macrophages and astrocytes.
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetHistamine Receptor
-
Recptorhistamine N-methyl transferase
-
Research AreaInfection
-
Indication——
Chemical Information
-
CAS Number6398-98-7
-
Formula Weight464.82
-
Molecular FormulaC20H28Cl3N3O3
-
Purity>98% (HPLC)
-
SolubilityWater: 10 mM
-
SMILESO.O.Cl.Cl.CCN(CC)CC1=C(O)C=CC(NC2=C3C=CC(Cl)=CC3=NC=C2)=C1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.de Villiers KA, et al. J Inorg Biochem. 2008 Aug;102(8):1660-7.
molnova catalog
related products
-
JNJ-5207852 dihydroc...
JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor. JNJ-5207852 is a potent dibasic amine antagonist that binds potently to rat H3 receptors (Ki=1.2?nm), and has good brain penetration. In ex vivo binding studies in mice, the compound had an ED50 of 0.13?mg?kg?1, subcutaneously.
-
SUVN-G3031
SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).
-
Dimaprit dihydrochlo...
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.
