Artemisinin( NSC 369397 )

Catalog No. M15429 CAS No. 63968-64-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Artemisinin
Note

Research use only, not for human use.
Brief Description

Artemisinin is a drug used to treat multi-drug resistant strains of falciparum malaria (as well as increasingly vivax malaria).
Description

Artemisinin is a drug used to treat multi-drug resistant strains of falciparum malaria (as well as increasingly vivax malaria). The compound is isolated from the plant Artemisia annua, a herb described in Chinese traditional medicine, though it is usually chemically modified and combined with other medications. The drug is also being studied as a treatment for Y.
In Vitro

Cell Cytotoxicity Assay Cell Line:PC12 cells Concentration:25 or 50 μM Incubation Time:24 hours Result:Protected and rescue PC12 cells against Aβ25-35-induced cell death.Cell Viability Assay Cell Line:RCC cells, RCC cell lines UMRC-2 and CAKI-2, and normal renal cell HK-2 Concentration:1, 5, 10, 50, and 100?μM Incubation Time:24 hours Result:Selectively inhibited cancer cell growth in a dose-dependent manner. Western Blot Analysis Cell Line:UMRC-2 and CAKI-2 cells Concentration:25, 50?μM Incubation Time:24 hours Result:Decreased pAKT in a dose-dependent manner.
In Vivo

Animal Model:4-6 weeks old male nude mice Dosage:20?mg/kg Administration:gavage; every day for two weeks Result:Suppressed UMRC-2 xenograft tumor growth.
Synonyms

NSC 369397
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Infection
Indication

——

CAS Number

63968-64-9
Formula Weight

282.33
Molecular Formula

C15H22O5
Purity

>98% (HPLC)
Solubility

Ethanol: 24 mg/mL (85.0 mM); DMSO: 57 mg/mL (201.89 mM)
SMILES

O=C1[C@H](C)[C@]2([H])CC[C@@H](C)[C@]3([H])CC[C@@](O4)(C)OO[C@]32[C@]4([H])O1
Chemical Name

(3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one

1.Mbengue A, et al. Nature. 2015 Apr 30;520(7549):683-7.

Calculator

molnova catalog