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LH-846

CAS No. 639052-78-1

LH-846( LH846 | LH-846 | LH 846 )

Catalog No. M15424 CAS No. 639052-78-1

LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.

Purity : >98% (HPLC)

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Biological Information

Product Name

LH-846
Note

Research use only, not for human use.
Brief Description

LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.
Description

LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.
In Vitro

LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells.
In Vivo

——
Synonyms

LH846 | LH-846 | LH 846
Pathway

Metabolic Enzyme/Protease
Target

Casein Kinase
Recptor

CK1
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

639052-78-1
Formula Weight

316.81
Molecular Formula

C16H13ClN2OS
Purity

>98% (HPLC)
Solubility

DMSO: 45 mg/mL
SMILES

O=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3
Chemical Name

N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Lee JW, et al. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-1

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