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NCC007
CAS No. 2342583-66-6
NCC007( —— )
Catalog No. M24065 CAS No. 2342583-66-6
NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 177 | In Stock |
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| 50MG | 309 | In Stock |
|
| 100MG | 462 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNCC007
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NoteResearch use only, not for human use.
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Brief DescriptionNCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
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DescriptionNCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
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In Vitro——
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In VivoNCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition. Animal Model:Adult C57BL/6J background male mice (8 weeks old)Dosage:5, 15 mM Administration:Infused into the lateral ventricle, constant dark conditionResult:Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorCKIα|CKIδ
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Research Area——
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Indication——
Chemical Information
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CAS Number2342583-66-6
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Formula Weight447.5
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Molecular FormulaC22H28F3N7
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Purity>98% (HPLC)
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SolubilityDMSO:120 mg/mL?(268.16mM;?Need ultrasonic)
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SMILESCC(C1CC1)n1c(nc(NCCN(C)C)nc2NCc3cccc(C(F)(F)F)c3)c2nc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase I伪 and 未. J Med Chem. 2019 Feb 28;62(4):1989-1998.
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