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L-α-Hydroxyglutaric acid disodium salt
L-α-Hydroxyglutaric acid disodium salt
CAS No. 63512-50-5
L-α-Hydroxyglutaric acid disodium salt( L-2-Hydroxyglutarate | L-2-HG )
Catalog No. M15402 CAS No. 63512-50-5
L-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutarate;L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 43 | In Stock |
|
| 25MG | 79 | In Stock |
|
| 50MG | 126 | In Stock |
|
| 100MG | 173 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameL-α-Hydroxyglutaric acid disodium salt
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NoteResearch use only, not for human use.
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Brief DescriptionL-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutarate;L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases.
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DescriptionL-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutarate;L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 0.628 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
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In VitroL-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes.
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In Vivo——
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SynonymsL-2-Hydroxyglutarate | L-2-HG
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorHistone Demethylase
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Research Area——
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Indication——
Chemical Information
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CAS Number63512-50-5
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Formula Weight194.1
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Molecular FormulaC5H6Na2O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 83.33 mg/mL (433.83 mM)
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SMILESC(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+]
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Chemical NamePentanedioic acid, 2-hydroxy-, disodium salt, (S)- (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.
2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
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