Methacholine Chloride

Research use only, not for human use.

Methacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of acetylcholine.

Methacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of acetylcholine. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (In Vivo):Methacholine choride (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs.Methacholine choride (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 μg/kg; i.v.) in a a dose-dependent manner in mouse.

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Methacholine choride (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs.Methacholine choride (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 μg/kg; i.v.) in a a dose-dependent manner in mouse. Animal Model:9-week female BALB/c mice Dosage:0.03, 0.1, 0.3, 1 mg/kg Administration:I.v.Result:Induced severe bronchoconstriction.

Methacholine

Endocrinology/Hormones

AChR

mAChR

Other Indications

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62-51-1

195.69

C8H18ClNO2

>98% (HPLC)

DMSO: 42mg/mL

CC(C[N+](C)(C)C)OC(=O)C.[Cl-]

2-acetyloxypropyl(trimethyl)azanium;chloride

(-20℃)

With Ice Pack

≥ 2 years