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Methacholine Chloride
CAS No. 62-51-1
Methacholine Chloride( Methacholine )
Catalog No. M15366 CAS No. 62-51-1
Methacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of acetylcholine.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 53 | In Stock |
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| 200MG | 78 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMethacholine Chloride
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NoteResearch use only, not for human use.
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Brief DescriptionMethacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of acetylcholine.
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DescriptionMethacholine chloride is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of acetylcholine. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (In Vivo):Methacholine choride (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs.Methacholine choride (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 μg/kg; i.v.) in a a dose-dependent manner in mouse.
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In Vitro——
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In VivoMethacholine choride (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs.Methacholine choride (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 μg/kg; i.v.) in a a dose-dependent manner in mouse. Animal Model:9-week female BALB/c mice Dosage:0.03, 0.1, 0.3, 1 mg/kg Administration:I.v.Result:Induced severe bronchoconstriction.
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SynonymsMethacholine
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptormAChR
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number62-51-1
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Formula Weight195.69
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Molecular FormulaC8H18ClNO2
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Purity>98% (HPLC)
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SolubilityDMSO: 42mg/mL
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SMILESCC(C[N+](C)(C)C)OC(=O)C.[Cl-]
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Chemical Name2-acetyloxypropyl(trimethyl)azanium;chloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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α-Bungarotoxin
Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM and > 3 μM respectively).
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Hodostin
Neostigmine methyl sulfate is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
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Proxyphylline
Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant vasodilator and bronchodilator.
