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ANT431 sodium
CAS No. ——
ANT431 sodium( ANT 431 | ANT-431 )
Catalog No. M17103 CAS No. ——
ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameANT431 sodium
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NoteResearch use only, not for human use.
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Brief DescriptionANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2.
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DescriptionANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively); potentiate the activity of meropenem (MEM) against a broad range of MBL-producing carbapenem-resistant Enterobacteriaceae (CRE), restore its efficacy against an Escherichia coli NDM-1 strain in a murine thigh infection model.
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In Vitro——
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In Vivo——
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SynonymsANT 431 | ANT-431
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight308.282
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Molecular FormulaC9H7N3NaO4S2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-(pyridine-3-sulfonamido)thiazole-4-carboxylic acid, sodium salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Everett M, et al. Antimicrob Agents Chemother. 2018 Mar 12. pii: AAC.00074-18.
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