(S)-HH2853( —— )

Catalog No. M36496 CAS No. 2202678-05-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

(S)-HH2853
Note

Research use only, not for human use.
Brief Description

(S)-HH2853 is a potent dual inhibitor of EZH1 and EZH2, inhibiting EZH2_Y641F with an IC50 of <100 nM.(S)-HH2853 has potential antitumor activity and can be used in the study of autoimmune diseases.
Description

(S)-HH2853 (compound 200), a PYRIDINO five membered aromatic ring compound, is a potent EZH1/2 dual inhibitor with an IC50 of <100 nM for EZH2_Y641F. (S)-HH2853 has the potential to be used in the research of anti-tumor or autoimmune diseases.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Histone Methyltransferase
Research Area

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Indication

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CAS Number

2202678-05-3
Formula Weight

611.66
Molecular Formula

C31H36F3N7O3
Purity

>98% (HPLC)
Solubility

——
SMILES

[C@H](C)(C=1N2C(=C(C=C2)C3=CC=C(C)N=N3)C=C(C(NCC4=C(OC)C=C(C)NC4=O)=O)C1C)N5CCN(CC(F)(F)F)CC5
Chemical Name

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1. Xuxing Chen, et al. PYRIDINO five membered aromatic ring compounds, preparation method and application thereof. WO2018045971A1.

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