Cart
sales@molnova.com
SB 742457
CAS No. 607742-69-8
SB 742457( GSK742457 )
Catalog No. M15279 CAS No. 607742-69-8
SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 61 | In Stock |
|
| 10MG | 98 | In Stock |
|
| 25MG | 200 | In Stock |
|
| 50MG | 320 | In Stock |
|
| 100MG | 507 | In Stock |
|
| 500MG | 1062 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSB 742457
-
NoteResearch use only, not for human use.
-
Brief DescriptionSB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63.
-
DescriptionSB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.(In Vitro):Intepirdine (SB742457), a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. Intepirdine (SB742457) is generally safe and well tolerated and may be efficacious in Alzheimer disease.
-
In VitroIntepirdine (SB742457), a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. Intepirdine (SB742457) is generally safe and well tolerated and may be efficacious in Alzheimer disease.
-
In Vivo——
-
SynonymsGSK742457
-
PathwayEndocrinology/Hormones
-
Target5-HT Receptor
-
Recptor5-HT6
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number607742-69-8
-
Formula Weight353.44
-
Molecular FormulaC19H19N3O2S
-
Purity>98% (HPLC)
-
SolubilityEthanol: 2 mg/mL (5.65 mM); DMSO: 78 mg/mL (220.68 mM)
-
SMILESO=S(C1=CC2=CC=CC(N3CCNCC3)=C2N=C1)(C4=CC=CC=C4)=O
-
Chemical Name3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Chuang ATT, et al. Alzheimers Dement, 2006, 2, S631–S632 (abstract).
molnova catalog
related products
-
Nortriptyline hydroc...
Nortriptyline hydrochloride is a tricyclic antidepressant used to relieve the symptoms of depression.
-
Cinitapride
Cinitapride is a gastroprokinetic agent. It slows the actions of the muscles to reduce the symptoms of conditions such as acid reflux, delayed gastric emptying, and ulcer dyspepsia.
-
Gamabufotalin
Gamabufotalin, a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.
