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SB 742457
CAS No. 607742-69-8
SB 742457( GSK742457 )
Catalog No. M15279 CAS No. 607742-69-8
SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
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| 5MG | 32 | In Stock |
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| 10MG | 50 | In Stock |
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| 25MG | 102 | In Stock |
|
| 50MG | 161 | In Stock |
|
| 100MG | 254 | In Stock |
|
| 200MG | 361 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB 742457
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NoteResearch use only, not for human use.
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Brief DescriptionSB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63.
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DescriptionSB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.(In Vitro):Intepirdine (SB742457), a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. Intepirdine (SB742457) is generally safe and well tolerated and may be efficacious in Alzheimer disease.
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In VitroIntepirdine (SB742457), a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. Intepirdine (SB742457) is generally safe and well tolerated and may be efficacious in Alzheimer disease.
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In Vivo——
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SynonymsGSK742457
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT6
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number607742-69-8
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Formula Weight353.44
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Molecular FormulaC19H19N3O2S
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Purity>98% (HPLC)
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SolubilityEthanol: 2 mg/mL (5.65 mM); DMSO: 78 mg/mL (220.68 mM)
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SMILESO=S(C1=CC2=CC=CC(N3CCNCC3)=C2N=C1)(C4=CC=CC=C4)=O
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Chemical Name3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chuang ATT, et al. Alzheimers Dement, 2006, 2, S631–S632 (abstract).
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