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Fexinidazole
CAS No. 59729-37-2
Fexinidazole( Fexinidazole | Hoe-239 | Hoe 239 | Hoe239 )
Catalog No. M15220 CAS No. 59729-37-2
Fexinidazole is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 104 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 305 | In Stock |
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| 100MG | 462 | In Stock |
|
| 200MG | 644 | In Stock |
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| 500MG | 1004 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFexinidazole
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NoteResearch use only, not for human use.
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Brief DescriptionFexinidazole is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani.
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DescriptionFexinidazole is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically relevant active metabolites in vivo are the sulfoxide and sulfone.(In Vitro):Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.(In Vivo):Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities.
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In VitroFexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.
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In VivoFexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities. Animal Model:Adult female NMRI mice weighing between 20 and 25 g T. b. rhodesienseDosage:20, 50 mg/kg (IP) or 25, 50, 100 mg/kg (PO) Administration:IP or PO; daily; four consecutive days Result:Had antitrypanosomal activities, with 100 mg/kg/day p.o. being 100% curative.
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SynonymsFexinidazole | Hoe-239 | Hoe 239 | Hoe239
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PathwayOthers
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TargetOther Targets
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Recptorantiparasitic
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number59729-37-2
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Formula Weight279.31
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Molecular FormulaC12H13N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESO=[N+](C1=CN=C(COC2=CC=C(SC)C=C2)N1C)[O-]
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Chemical Name1-Methyl-2-((p-(methylthio)phenoxy)methyl)-5-nitroimidazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Raether W, Seidenath H. Ann Trop Med Parasitol. 1983 Feb;77(1):13-26.
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