Fexinidazole

Research use only, not for human use.

Fexinidazole is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani.

Fexinidazole is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically relevant active metabolites in vivo are the sulfoxide and sulfone.(In Vitro):Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.(In Vivo):Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities.

Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.

Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities. Animal Model:Adult female NMRI mice weighing between 20 and 25 g T. b. rhodesienseDosage:20, 50 mg/kg (IP) or 25, 50, 100 mg/kg (PO) Administration:IP or PO; daily; four consecutive days Result:Had antitrypanosomal activities, with 100 mg/kg/day p.o. being 100% curative.

Fexinidazole | Hoe-239 | Hoe 239 | Hoe239

Others

Other Targets

antiparasitic

Infection

——

59729-37-2

279.31

C12H13N3O3S

>98% (HPLC)

DMSO: 10 mM

O=[N+](C1=CN=C(COC2=CC=C(SC)C=C2)N1C)[O-]

1-Methyl-2-((p-(methylthio)phenoxy)methyl)-5-nitroimidazole

(-20℃)

With Ice Pack

≥ 2 years