Menadione( Menadione | NSC 4170 )

Catalog No. M15137 CAS No. 58-27-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Menadione
Note

Research use only, not for human use.
Brief Description

Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.
Description

Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.
In Vitro

Cell Proliferation Assay Cell Line:AR4-2J cells Concentration:0-100 μM Incubation Time:24-72 h Result:Inhibited cell proliferation in time- and dose-dependently manner at lower concentrations (1-20 μM).Western Blot Analysis Cell Line:AR4-2J cells Concentration:0-100 μM Incubation Time:24 h Result:Induced wild-type P53 at the dose of 1-20 μM.Induced a low level of wild-type P53 at the dose of 100 μM.
In Vivo

Animal Model:Male Wister ratsDosage:25-150 mg/kg Administration:i.v., once time or every other day for five times Result:Showed microgranular degeneration of renal tubular cells at the dose of 25 mg/kg.Observed microgranular degeneration of renal tubular cells and mild pulmonary hemorrhage at the dose of 50 mg/kg.Produced lesions in the kidney, heart, liver and lung at the dose of 100-150 mg/kg.Showed kidney apoptosis at the dose of 100-150 mg/kg.
Synonyms

Menadione | NSC 4170
Pathway

Autophagy
Target

Thrombin
Recptor

Thrombin| VK
Research Area

Other Indications
Indication

——

1.Wang Z, et al. Hepatology. 1995 Sep; 22(3):876-82.

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