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Closantel
CAS No. 57808-65-8
Closantel( NSC 335306 )
Catalog No. M15114 CAS No. 57808-65-8
A veterinary anthelmintic with known proton ionophore activities; is identified as a potent and specific inhibitor of filarial chitinases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
|
| 50MG | 32 | In Stock |
|
| 100MG | 50 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 120 | In Stock |
|
| 1G | 179 | In Stock |
|
Biological Information
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Product NameClosantel
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NoteResearch use only, not for human use.
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Brief DescriptionA veterinary anthelmintic with known proton ionophore activities; is identified as a potent and specific inhibitor of filarial chitinases.
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DescriptionA veterinary anthelmintic with known proton ionophore activities; is identified as a potent and specific inhibitor of filarial chitinases; also shows to be an allosteric inhibitor of SPAK and OSR1.Parasite Infection Approved(In Vitro):Closantel, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase.
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In VitroClosantel, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase.
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In Vivo——
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SynonymsNSC 335306
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PathwayMicrobiology/Virology
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TargetParasite
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RecptorAntiparasitic
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Research AreaInfection
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IndicationParasite Infection
Chemical Information
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CAS Number57808-65-8
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Formula Weight663.0737
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Molecular FormulaC22H14Cl2I2N2O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 49 mg/mL
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SMILESCC1=CC(C(C#N)C2=CC=C(Cl)C=C2)=C(Cl)C=C1NC(=O)C1=CC(I)=CC(I)=C1O
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Chemical NameBenzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. AlAmri MA, et al. ChemMedChem. 2017 May 9;12(9):639-645.
2. Gloeckner C, et al. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3424-9.
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