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Fexaramine
CAS No. 574013-66-4
Fexaramine( Fexaramine )
Catalog No. M15095 CAS No. 574013-66-4
A potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 111 | In Stock |
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| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 183 | In Stock |
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| 50MG | 304 | In Stock |
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| 100MG | 454 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFexaramine
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064.
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DescriptionA potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064; shows no transcriptional activity against hRXRα, hPPARα/γ/δ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, and hVDR; strongly induces target genes SHP, PLTP BSEP, and MRP-2 in the HEPG2 liver cell system; robustly induces FGF15, leading to alterations in BA composition.
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In Vitro——
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In Vivo——
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SynonymsFexaramine
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PathwayMetabolic Enzyme/Protease
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TargetFXR
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RecptorFXR
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number574013-66-4
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Formula Weight496.6398
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Molecular FormulaC32H36N2O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(OC)/C=C/C1=CC=CC(N(C(C2CCCCC2)=O)CC3=CC=C(C4=CC=C(N(C)C)C=C4)C=C3)=C1
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Chemical Name2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-, methyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Downes M, et al. Mol Cell. 2003 Apr;11(4):1079-92.
2. Fang S, et al. Nat Med. 2015 Feb;21(2):159-65.
3. Cho SW, et al. J Bone Miner Res. 2013 Oct;28(10):2109-21.
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