Glyco-Obeticholic acid( —— )

Catalog No. M24861 CAS No. 863239-60-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Glyco-Obeticholic acid
Note

Research use only, not for human use.
Brief Description

Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
Description

Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
In Vitro

Obeticholic acid is conjugated with glycine in the liver to form glycol-obeticholic acid, which is secreted into bile. Microorganisms in the ileum and colon can deconjugate glyco-obeticholic acid, converting it into the parent drug, which may then be reabsorbed or excreted in faeces.
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

FXR
Recptor

FXR
Research Area

——
Indication

——

CAS Number

863239-60-5
Formula Weight

477.68
Molecular Formula

C28H47NO5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)CNC(CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
Chemical Name

——

1.Markham A, et al. Obeticholic Acid: First Global Approval. Drugs. 2016 Aug;76(12):1221-6.

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