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Rapamycin

CAS No. 53123-88-9

Rapamycin( Sirolimus )

Catalog No. M14886 CAS No. 53123-88-9

A macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 41 In Stock
10MG 29 In Stock
25MG 38 In Stock
50MG 45 In Stock
100MG 59 In Stock
200MG 100 In Stock
500MG 184 In Stock
1G 276 In Stock
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Biological Information

  • Product Name
    Rapamycin
  • Note
    Research use only, not for human use.
  • Brief Description
    A macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).
  • Description
    A macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).Other Indication Approved(In Vitro):Rapamycin (GMP) (1 nM; 2-3 weeks) induces in vitro differentiation of human embryonic stem cell (hESCs) into mineralized osteoblasts.Rapamycin (GMP) (1 nM; 2-3 weeks) enhances the osteoblastic differentiation of human embryoid bodies (hEBs).Rapamycin (GMP) (20 nM; 4 h) serum-dependently promotes vascular smooth muscle cells (VSMCs) differentiation.Rapamycin (GMP) induces osteoblastic differentiation in rat osteoblast-like osteosarcoma cells.
  • In Vitro
    Rapamycin (GMP) (1 nM; 2-3 weeks) induces in vitro differentiation of human embryonic stem cell (hESCs) into mineralized osteoblasts.Rapamycin (GMP) (1 nM; 2-3 weeks) enhances the osteoblastic differentiation of human embryoid bodies (hEBs).Rapamycin (GMP) (20 nM; 4 h) serum-dependently promotes vascular smooth muscle cells (VSMCs) differentiation.Rapamycin (GMP) induces osteoblastic differentiation in rat osteoblast-like osteosarcoma cells.
  • In Vivo
    ——
  • Synonyms
    Sirolimus
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    mTOR
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    53123-88-9
  • Formula Weight
    914.1719
  • Molecular Formula
    C51H79NO13
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    C[C@@H](C([C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(C[C@@H]([C@H](C)C[C@@H]1CC[C@@H](O)C(OC)C1)OC2=O)=O)=O)C[C@H](C)/C=C/C=C/C=C(C)/[C@@H](OC)C[C@H]3O[C@](C(C(N4[C@H]2CCCC4)=O)=O)(O)[C@H](C)CC3
  • Chemical Name
    Rapamycin

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Morris RE, et al. Transplant Proc. 1991 Feb;23(1 Pt 1):521-4. 2. Dumont FJ, et al. J Immunol. 1990 Jan 1;144(1):251-8. 3. Dumont FJ, et al. J Immunol. 1990 Feb 15;144(4):1418-24. 4. Edwards SR, et al. J Biol Chem. 2007 May 4;282(18):13395-401.
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