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ASP-6537
CAS No. 524699-72-7
ASP-6537( ASP6537 | ASP6537 | FK-881 | FK 881 | FR 122047 )
Catalog No. M14855 CAS No. 524699-72-7
ASP-6537 (ASP6537) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameASP-6537
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NoteResearch use only, not for human use.
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Brief DescriptionASP-6537 (ASP6537) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM.
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DescriptionASP-6537 (ASP6537) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM; displays 650-fold selectivity over COX-2 (IC50=3.2 uM); dose dependently inhibits carrageenan-induced paw edema (ED30=22 mg/kg) and paw swelling associated with adjuvant arthritis (ED50=17 mg/kg) in rats; also inhibits TXA2 production more selectively than aspirin in in vitro and in vivo, exerts potent antithrombotic effect in rats.
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In Vitro——
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In Vivo——
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SynonymsASP6537 | ASP6537 | FK-881 | FK 881 | FR 122047
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research Area——
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Indication——
Chemical Information
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CAS Number524699-72-7
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Formula Weight311.341
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Molecular FormulaC17H17N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=CC=C(C2=NC(OC)=NN2C3=CC=C(OC)C=C3)C=C1
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Chemical Name3-methoxy-1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Imanishi J, et al. Biochem Pharmacol. 2011 Oct 1;82(7):746-54.
2. Sakata C, et al. Thromb Res. 2013 Jul;132(1):56-62.
3. Sakata C, et al. Eur J Pharmacol. 2017 Mar 5;798:72-76.
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