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Angiotensin 1-7
CAS No. 51833-78-4
Angiotensin 1-7( Angiotensin (1-7) )
Catalog No. M14812 CAS No. 51833-78-4
Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 114 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAngiotensin 1-7
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NoteResearch use only, not for human use.
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Brief DescriptionAngiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS).
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DescriptionAngiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM; augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide, abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2; evokes anti-arrhythmogenic effects in animal models, upregulates cardiac nitric oxide synthase in spontaneously hypertensive rats.
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In VitroAngiotensin 1-7 (Ang-(1-7)) inhibits cultured vascular smooth muscle cell growth, whereas equal molar concentration of Ang II stimulates cell growth.Angiotensin 1-7 (Ang 1-7) abrogates the methylglyoxal-modified albumin (MGA)-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-β-ERK pathway in NRK-52E cells.?Angiotensin 1-7 signals through the Mas receptor ( MasR) in opposition to Ang II/angiotensin II type 1 receptor (AT1R), promoting anti-inflammatory,vasodilatory, and neuroprotective effects.
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In VivoDaily Angiotensin 1-7 (Ang-(1-7)) treatment (0.01-0.06 mg/kg) results in significant amelioration of DSS-induced colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt is reduced by Ang 1-7 treatment.
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SynonymsAngiotensin (1-7)
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PathwayGPCR/G Protein
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TargetAngiotensin Receptor
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RecptorAngiotensin Receptor
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number51833-78-4
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Formula Weight899.0048
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Molecular FormulaC41H62N12O11
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 30.2 mg/mL
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SMILESO=C(O)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O)CCC1
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Chemical Name1-7-Angiotensin II, 5-L-isoleucine-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li P, et al. Hypertension. 1997 Jan;29(1 Pt 2):394-400.
2. Alzayadneh EM, et al. Cell Signal. 2014 Dec;26(12):3027-35.
3. Averill DB, et al. Circulation. 2003 Oct 28;108(17):2141-6.
4. Costa MA, et al. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1205-11.
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