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UMI-77

CAS No. 518303-20-3

UMI-77( UMI-77, UMI77, UMI 77 )

Catalog No. M14810 CAS No. 518303-20-3

A potent and selective Mcl-1 inhibitor with Ki of 0.49 uM; displays >10 fold selectivity against Bcl-w, Bfl-1, Bcl-xL and Bcl-2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 72 In Stock
10MG 110 In Stock
25MG 200 In Stock
50MG 332 In Stock
100MG 478 In Stock
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Biological Information

  • Product Name
    UMI-77
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective Mcl-1 inhibitor with Ki of 0.49 uM; displays >10 fold selectivity against Bcl-w, Bfl-1, Bcl-xL and Bcl-2.
  • Description
    A potent and selective Mcl-1 inhibitor with Ki of 0.49 uM; displays >10 fold selectivity against Bcl-w, Bfl-1, Bcl-xL and Bcl-2; inhibits cell growth and induces apoptosis in pancreatic cancer cells; blocks the heterodimerization of Mcl-1/Bax and Mcl-1/Bak in cells; inhibits tumor growth in BxPC-3 xenograft model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    UMI-77, UMI77, UMI 77
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Mcl-1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    518303-20-3
  • Formula Weight
    468.3415
  • Molecular Formula
    C18H14BrNO5S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br
  • Chemical Name
    Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Abulwerdi F, et al. Mol Cancer Ther. 2014 Mar;13(3):565-75. 2. Mohammad RM, et al. Semin Cancer Biol. 2015 Dec;35 Suppl:S78-103. 3. Korfi K, et al. Cell Death Dis. 2016 Apr 7;7:e2177.
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