2-Pyridinealdoxime methochloride

Research use only, not for human use.

Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning.

Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents) in conjunction with atropine and diazepam.(In Vivo):Pralidoxime chloride (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice.

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Pralidoxime chloride (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice. Animal Model:F1B6D2 mice (male, administered subcutaneously diethylparaoxon)Dosage:10, 50, 100, and 150 mg/kg Administration:Intramuscular administration, once Result:Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.

2-PAM

Endocrinology/Hormones

AChR

AchE

Neurological Disease

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51-15-0

172.61

C7H9ClN2O

>98% (HPLC)

DMSO: 10 mM

CN1C=CC=CC1=C[NH+]=O.[Cl-]

[(E)-(1-methylpyridin-2-ylidene)methyl]-oxoazanium;chloride

(-20℃)

With Ice Pack

≥ 2 years