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Home - Products - Endocrinology/Hormones - AChR - JHU 37152

JHU 37152

CAS No. 2369979-67-7

JHU 37152( —— )

Catalog No. M24084 CAS No. 2369979-67-7

JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
10MG 29 In Stock
25MG 54 In Stock
50MG 84 In Stock
100MG 136 In Stock
200MG 204 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    JHU 37152
  • Note
    Research use only, not for human use.
  • Brief Description
    JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively.
  • Description
    JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
  • In Vitro
    JHU37152 displays high DREADD affinity, with Kis of 1.8?nM and 8.7?nM for hM3Dq and hM4Di expressed in mouse brain sections.JHU37152 (1-1000 nM) selectively displaces [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites.
  • In Vivo
    JHU37152 (0.1 mg/kg; i.p.) exhibits high DREADD occupancy in mice and rats.JHU37152 (0.01-1 mg/kg; i.p.) selectively inhibits locomotor activity in D1-hM3Dq and D1-hM4Di mice without any significant locomotor effects observed in WT mice.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    M3 mAChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2369979-67-7
  • Formula Weight
    358.85
  • Molecular Formula
    C19H20ClFN4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:72 mg/mL (200.65 mM);Ethanol:24 mg/mL (66.88 mM)
  • SMILES
    FC1=C2C(NC3=CC=C(Cl)C=C3N=C2N4CCN(CC)CC4)=CC=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bonaventura J , Eldridge M , Hu F , et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys[J]. Nature Communications, 2019, 10(1).
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