p-Coumaric acid

Research use only, not for human use.

Actions Hydroxycinnamic acid found in many fruits and vegetables.

Actions Hydroxycinnamic acid found in many fruits and vegetables. Other Notes :Predominantly trans isomer.

Cell Proliferation Assay Cell Line:A375, B16Concentration:1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5 mM Incubation Time:24, 48 h Result:Inhibited the proliferation of A375 and B16 cells The IC50 values on A375 cells were 4.4 mM and 2.5 mM , and the IC50 values on B16 cells were 4.1 mM and 2.8 mM in 24 and 48 h, respectively.Cell Cycle Analysis Cell Line:A375, B16 Concentration:1.5, 2.5, 3 mM;2, 3, 4 mM Incubation Time:24 h Result:Increased the S phase proportion in A375 cells and the G0/G1 phase proportion in B16 cells.Western Blot Analysis Cell Line:A375, B16 Concentration:1.5, 2.5, 3 mM;2, 3, 4 mM Incubation Time:24 h Result:Reduced the expression levels of CDK2 and Cyclin A in A375 cells and the levels of CDK2 and Cyclin E in B16 cells.Decreased the levels of caspase-3 and caspase-9 and increased the levels of cleaved caspase-3 and cleaved caspase-9. Downregulated Bcl-2 and upregulated Bax, Apaf1, and cytoplasmic Cyto-C levels.

Animal Model:DMH-induced colonic preneoplastic lesions in ratsDosage:50, 100, 200 mg/kg Administration:suspended in 0.5% carboxymethylcellulose (CMC) and administered every day via intragastric intubation Result: Reduced the polyp incidence to 71.42%, 57.14% and 42.85% respectively.Reduced the ACF and DACF in a dose-dependent manner and the β– catenin immune activity.Decreased levels of TBARS and increased levels of SOD, CAT and GPx.Decreased the activity of β-glucuronidase, and mucinase.Animal Model:Doxorubicin-induced nephrotoxicity rats Dosage:15, 100 mg/kg Administration: p.o.Result:Decreased serum creatinine, BUN and lipid peroxidation, IL-1β and TNF-α.Decreased the number of TUNEL-positive cells.

trans-p-hydroxy Cinnamic Acid | trans-para-hydroxy Cinnamic Acid

Others

Other Targets

Others

Other Indications

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501-98-4

164.16

C9H8O3

>98% (HPLC)

DMSO: 10 mM

C1=CC(=CC=C1/C=C/C(=O)O)O

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(-20℃)

With Ice Pack

≥ 2 years