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EX 527 (Selisistat)
CAS No. 49843-98-3
EX 527 (Selisistat)( Selisistat )
Catalog No. M14668 CAS No. 49843-98-3
EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
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| 10MG | 47 | In Stock |
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| 25MG | 85 | In Stock |
|
| 50MG | 129 | In Stock |
|
| 100MG | 222 | In Stock |
|
| 200MG | 331 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEX 527 (Selisistat)
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NoteResearch use only, not for human use.
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Brief DescriptionEX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.
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DescriptionEX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.(In Vitro):Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.(In Vivo):Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).
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In VitroSelisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.
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In VivoSelisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).
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SynonymsSelisistat
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSIRT1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number49843-98-3
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Formula Weight248.71
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Molecular FormulaC13H13ClN2O
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Purity>98% (HPLC)
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SolubilityDMSO:50 mg/mL (201.03 mM); Ethanol:18 mg/mL (72.37 mM); Water:<1 mg/mL (<1 mM)
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SMILESO=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
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Chemical Name6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Solomon JM, et al. Mol Cell Biol, 2006, 26(1), 28-38.
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