SIRT6-IN-5

Research use only, not for human use.

SIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.

SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects.

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Chromatin/Epigenetic

Sirtuin

Sirtuin

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891002-11-2

366.32

C19H14N2O6

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (170.62 mM; Ultrasonic )

N(C(=O)C1=CC=C(NC(=O)C2=CC=CO2)C=C1)C3=CC(C(O)=O)=C(O)C=C3

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(-20℃)

With Ice Pack

≥ 2 years