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NESS-0327
CAS No. 494844-07-4
NESS-0327( NESS 0327 | NESS0327 )
Catalog No. M14656 CAS No. 494844-07-4
A potent, selective CB1 cannabinoid receptor antagonist with Ki of 350 fM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 428 | In Stock |
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| 50MG | 719 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNESS-0327
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective CB1 cannabinoid receptor antagonist with Ki of 350 fM.
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DescriptionA potent, selective CB1 cannabinoid receptor antagonist with Ki of 350 fM, >60,000-fold selective for the CB1 receptor versus CB2 receptor (Ki=21 nM); antagonizes WIN 55,212-2-stimulated [35S]GTPgammaS binding, antagonizes the inhibitory effects of WIN 55,212-2 on electrically evoked contractions in mouse isolated vas deferens preparations with pA2 12.46; inhibits the antinociceptive effect produced by WIN 55,212-2 (2 mg/kg s.c.) in both tail-flick (ID50=0.042 mg/kg i.p.) and hot-plate test (ID50=0.018 mg/kg i.p.).
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In Vitro——
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In Vivo——
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SynonymsNESS 0327 | NESS0327
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number494844-07-4
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Formula Weight489.8
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Molecular FormulaC24H23Cl3N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 9.7 mg/mL (19.80 mM)
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SMILESO=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C3=C1CCCC4=CC(Cl)=CC=C43)NN5CCCCC5
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Chemical NameN-piperidinyl-[8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo [6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ruiu S, et al. J Pharmacol Exp Ther. 2003 Jul;306(1):363-70.
2. Tambaro S, et al. Eur J Pharmacol. 2005 Nov 21;525(1-3):150-3.
3. Murineddu G, et al. J Med Chem. 2005 Nov 17;48(23):7351-62.
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