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Elesclomol

CAS No. 488832-69-5

Elesclomol( STA-4783 | STA4783 | STA 4783 )

Catalog No. M14641 CAS No. 488832-69-5

Elesclomol (STA-4783) is a small-molecule oxidative stress inducer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 37 In Stock
5MG 32 In Stock
10MG 56 In Stock
25MG 88 In Stock
50MG 119 In Stock
100MG 152 In Stock
200MG 226 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Elesclomol
  • Note
    Research use only, not for human use.
  • Brief Description
    Elesclomol (STA-4783) is a small-molecule oxidative stress inducer.
  • Description
    Elesclomol (STA-4783) is a small-molecule oxidative stress inducer, exerts selective cytotoxicity by increasing intracellular concentrations of reactive oxygen species (ROS) and induces cell death via mitochondrial apoptosisin cancer cells; selectively kills cisplatin-resistant tumor cells through increased ROS, markedly enhances the therapeutic index of paclitaxel against human tumor xenograft models. Ovarian Cancer Phase 2 Clinical.
  • In Vitro
    Apoptosis AnalysisCell Line:HSB2 cells Concentration:200 nM Incubation Time:18 hours Result:Increased the number of early and late apoptotic cells.
  • In Vivo
    Animal Model:Cardiac Ctr1 knockout mice Dosage:10 mg/kg Administration:Subcutaneous injection; every three days from post-natal day 5 to 26 and once weekly until post-natal day 54 Result:Ameliorated severe cardiac pathology with a partial reduction in hypertrophy.
  • Synonyms
    STA-4783 | STA4783 | STA 4783
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    HSP70
  • Research Area
    Cancer
  • Indication
    Ovarian Cancer

Chemical Information

  • CAS Number
    488832-69-5
  • Formula Weight
    400.5177
  • Molecular Formula
    C19H20N4O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 22 mg/mL
  • SMILES
    O=C(NN(C)C(C1=CC=CC=C1)=S)CC(NN(C)C(C2=CC=CC=C2)=S)=O
  • Chemical Name
    Propanedioic acid, 1,3-bis[2-methyl-2-(phenylthioxomethyl)hydrazide]

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Berkenblit A, et al. Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):584-90. 2. Kirshner JR, et al. Mol Cancer Ther. 2008 Aug;7(8):2319-27. 3. Wangpaichitr M, et al. Cancers (Basel). 2009;1(1):23-38. 4. Kluza J, et al. Cancer Res. 2012 Oct 1;72(19):5035-47.
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