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Elesclomol

CAS No. 488832-69-5

Elesclomol( STA-4783 | STA4783 | STA 4783 )

Catalog No. M14641 CAS No. 488832-69-5

Elesclomol (STA-4783) is a small-molecule oxidative stress inducer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 31 In Stock
10MG 53 In Stock
25MG 85 In Stock
50MG 115 In Stock
100MG 147 In Stock
200MG 219 In Stock
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Biological Information

  • Product Name
    Elesclomol
  • Note
    Research use only, not for human use.
  • Brief Description
    Elesclomol (STA-4783) is a small-molecule oxidative stress inducer.
  • Description
    Elesclomol (STA-4783) is a small-molecule oxidative stress inducer, exerts selective cytotoxicity by increasing intracellular concentrations of reactive oxygen species (ROS) and induces cell death via mitochondrial apoptosisin cancer cells; selectively kills cisplatin-resistant tumor cells through increased ROS, markedly enhances the therapeutic index of paclitaxel against human tumor xenograft models. Ovarian Cancer Phase 2 Clinical.
  • In Vitro
    Apoptosis AnalysisCell Line:HSB2 cells Concentration:200 nM Incubation Time:18 hours Result:Increased the number of early and late apoptotic cells.
  • In Vivo
    Animal Model:Cardiac Ctr1 knockout mice Dosage:10 mg/kg Administration:Subcutaneous injection; every three days from post-natal day 5 to 26 and once weekly until post-natal day 54 Result:Ameliorated severe cardiac pathology with a partial reduction in hypertrophy.
  • Synonyms
    STA-4783 | STA4783 | STA 4783
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    HSP70
  • Research Area
    Cancer
  • Indication
    Ovarian Cancer

Chemical Information

  • CAS Number
    488832-69-5
  • Formula Weight
    400.5177
  • Molecular Formula
    C19H20N4O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 22 mg/mL
  • SMILES
    O=C(NN(C)C(C1=CC=CC=C1)=S)CC(NN(C)C(C2=CC=CC=C2)=S)=O
  • Chemical Name
    Propanedioic acid, 1,3-bis[2-methyl-2-(phenylthioxomethyl)hydrazide]

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Berkenblit A, et al. Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):584-90. 2. Kirshner JR, et al. Mol Cancer Ther. 2008 Aug;7(8):2319-27. 3. Wangpaichitr M, et al. Cancers (Basel). 2009;1(1):23-38. 4. Kluza J, et al. Cancer Res. 2012 Oct 1;72(19):5035-47.
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