Triparanol
CAS No. 78-41-1
Triparanol( NSC 65345 | NSC-65345 | NSC65345 )
Catalog No. M27836 CAS No. 78-41-1
Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 690 | In Stock |
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| 5MG | 644 | In Stock |
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| 10MG | 866 | In Stock |
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| 25MG | 1283 | In Stock |
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| 50MG | 1665 | In Stock |
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| 100MG | 2297 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTriparanol
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NoteResearch use only, not for human use.
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Brief DescriptionTriparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling.
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DescriptionTriparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.(In Vitro):Triparanol is an effective cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase. Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer, and melanoma cells, and growth inhibition can be rescued by the exogenous addition of cholesterol.
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In VitroTriparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer and melanoma cells, and growth inhibition can be rescued by exogenous addition of cholesterol.
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In Vivo——
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SynonymsNSC 65345 | NSC-65345 | NSC65345
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PathwayApoptosis
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TargetApoptosis
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RecptorA2A/A1
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Research Area——
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Indication——
Chemical Information
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CAS Number78-41-1
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Formula Weight438.01
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Molecular FormulaC27H32ClNO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (114.16 mM)
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SMILESCCN(CC)CCOc1ccc(cc1)C(O)(Cc1ccc(Cl)cc1)c1ccc(C)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Cholesteryl Hemisucc...
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AZD-4877
AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis.
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3-O-Methylgallic aci...
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