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Alvespimycin hydrochloride

CAS No. 467214-21-7

Alvespimycin hydrochloride( 17-DMAG | KOS-1022 | NSC 707545 )

Catalog No. M14563 CAS No. 467214-21-7

A potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Alvespimycin hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.
  • Description
    A potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM; also show comparable binding affinity for Grp94 with EC50 of 65 nM; inhibits the migration and the extracellular matrix-invasiveness of HUVEC in vitro, also inhibits FGF-2 and VEGF-induced HUVEC proliferation and induces apoptosis.Blood Cancer Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    17-DMAG | KOS-1022 | NSC 707545
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    467214-21-7
  • Formula Weight
    653.2065
  • Molecular Formula
    C32H49ClN4O8
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 50 mg/mL
  • SMILES
    NC(O[C@@H](/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC1=C2OCCN(C)C)[C@@H](OC)/C=C\C=C(C)\C(NC(C1=O)=CC2=O)=O)=O.[H]Cl
  • Chemical Name
    Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jez JM, et al. Jez JM, 2. Bull EE, et al. Clin Cancer Res. 2004 Dec 1;10(23):8077-84. 3. Kaur G, et al. Clin Cancer Res. 2004 Jul 15;10(14):4813-21. 4. Ge J, et al. J Med Chem. 2006 Jul 27;49(15):4606-15.
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