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EMD-281014
CAS No. 443144-26-1
EMD-281014( Pruvanserin | LSN2411347 | LY-2422347 )
Catalog No. M14512 CAS No. 443144-26-1
EMD-281014 (Pruvanserin, LSN2411347, LY-2422347) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameEMD-281014
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NoteResearch use only, not for human use.
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Brief DescriptionEMD-281014 (Pruvanserin, LSN2411347, LY-2422347) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM.
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DescriptionEMD-281014 (Pruvanserin, LSN2411347, LY-2422347) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM, displays little to no affinity for 5-HT2C receptors (Ki=557 nM), human D2 receptors and IKr channels; significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test; reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset.Sleep Disorder Discontinued.
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In Vitro——
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In Vivo——
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SynonymsPruvanserin | LSN2411347 | LY-2422347
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaNeurological Disease
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IndicationSleep Disorder
Chemical Information
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CAS Number443144-26-1
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Formula Weight376.435
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Molecular FormulaC22H21FN4O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CN(CCN1CCC2=CC=C(C=C2)F)C(=O)C3=CC=CC4=C3NC=C4C#N
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Chemical Name7-[[4-[2-(4-Fluorophenyl)ethyl]-1-piperazinyl]carbonyl]-1H-indole-3-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hamadjida A, et al. Neuropharmacology. 2018 Jun 30;139:61-67.
2. Lauffer L, et al. J Pharmacol Exp Ther. 2016 Jul;358(1):39-49.
3. Patel JG, et al. Synapse. 2004 Apr;52(1):73-5.
4. Ladduwahetty T, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3201-4.
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