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CCT-031374 hydrobromide
CAS No. 1219184-91-4
CCT-031374 hydrobromide( CCT031374 hydrobromide )
Catalog No. M10825 CAS No. 1219184-91-4
A novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
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| 5MG | 62 | In Stock |
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| 10MG | 102 | In Stock |
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| 25MG | 207 | In Stock |
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| 50MG | 323 | In Stock |
|
| 100MG | 461 | In Stock |
|
| 200MG | 607 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCCT-031374 hydrobromide
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NoteResearch use only, not for human use.
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Brief DescriptionA novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay.
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DescriptionA novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay; promotes β-catenin degradation and lowers β-catenin levels in mouse L-cells, blockes the growth of a number of cancer cell lines including SW480 colon cancer cells (IC50=13.2 uM); blocks free β-catenin levels in BIO-stimulated HEK293 cells.
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In Vitro——
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In Vivo——
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SynonymsCCT031374 hydrobromide
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PathwayWnt/Notch/Hedgehog
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TargetBeta-catenin
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RecptorBeta-catenin
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Research Area——
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Indication——
Chemical Information
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CAS Number1219184-91-4
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Formula Weight434.33
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Molecular FormulaC23H19N3O.HBr
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C4=CC=C(C5=CC=CC=C5)C=C4)CN1C3=C(C=CC=C3)N2C1=NCC2.Br
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Chemical Name1-([1,1'-biphenyl]-4-yl)-2-(2,3-dihydro-9H-benzo[d]imidazo[1,2-a]imidazol-9-yl)ethan-1-one hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73.
2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91.
3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82.
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