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Home - Products - MAPK/ERK Signaling - p38 MAPK - CMPD-1

CMPD-1

CAS No. 41179-33-3

CMPD-1( CMPD 1 | CMPD1 )

Catalog No. M14412 CAS No. 41179-33-3

A potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 110 In Stock
5MG 101 In Stock
10MG 155 In Stock
25MG 281 In Stock
50MG 433 In Stock
100MG 671 In Stock
200MG Get Quote In Stock
500MG 1572 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    CMPD-1
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM.
  • Description
    A potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM; dose not prevents p38α-mediated phosphorylation of MBP and ATF-2; induces a significant G2/M arrest, also inhibits tubulin polymerization in glioblastoma cells.
  • In Vitro
    CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2.CMPD1 induced mitotic arrest and apoptosis in U87 cells.CMPD1 inhibits tubulin polymerisation in glioblastoma cells.
  • In Vivo
    ——
  • Synonyms
    CMPD 1 | CMPD1
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    p38 MAPK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    41179-33-3
  • Formula Weight
    349.4
  • Molecular Formula
    C22H20FNO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (286.20 mM)
  • SMILES
    O=C(NC1=CC=C(O)C=C1)CCCC2=CC=C(C3=CC=CC=C3F)C=C2
  • Chemical Name
    4-(2'-fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Davidson W, et al. Biochemistry. 2004 Sep 21;43(37):11658-71. 2. Gurgis F, et al. Cell Death Discov. 2015 Sep 7;1:15028.
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