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CMPD-1
CAS No. 41179-33-3
CMPD-1( CMPD 1 | CMPD1 )
Catalog No. M14412 CAS No. 41179-33-3
A potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 110 | In Stock |
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| 5MG | 101 | In Stock |
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| 10MG | 155 | In Stock |
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| 25MG | 281 | In Stock |
|
| 50MG | 433 | In Stock |
|
| 100MG | 671 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1572 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCMPD-1
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM.
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DescriptionA potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM; dose not prevents p38α-mediated phosphorylation of MBP and ATF-2; induces a significant G2/M arrest, also inhibits tubulin polymerization in glioblastoma cells.
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In VitroCMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2.CMPD1 induced mitotic arrest and apoptosis in U87 cells.CMPD1 inhibits tubulin polymerisation in glioblastoma cells.
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In Vivo——
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SynonymsCMPD 1 | CMPD1
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number41179-33-3
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Formula Weight349.4
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Molecular FormulaC22H20FNO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (286.20 mM)
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SMILESO=C(NC1=CC=C(O)C=C1)CCCC2=CC=C(C3=CC=CC=C3F)C=C2
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Chemical Name4-(2'-fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Davidson W, et al. Biochemistry. 2004 Sep 21;43(37):11658-71.
2. Gurgis F, et al. Cell Death Discov. 2015 Sep 7;1:15028.
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