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L-870810

CAS No. 410544-95-5

L-870810( L 870810 | L870810 )

Catalog No. M14410 CAS No. 410544-95-5

A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    L-870810
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties.
  • Description
    A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties; exhibits broad-spectrum activity against WT and multidrug-resistant HIV-1, HIV-2, and SIV; orally bioavailable.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    L 870810 | L870810
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    410544-95-5
  • Formula Weight
    430.454
  • Molecular Formula
    C20H19FN4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=NC(N(CCCC2)S2(=O)=O)=C3C=CC=NC3=C1O)NCC4=CC=C(F)C=C4
  • Chemical Name
    5-(1,1-dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-8-hydroxy-1,6-naphthyridine-7-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hazuda DJ, et al. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11233-8. 2. Zeng LF, et al. J Med Chem. 2012 Nov 26;55(22):9492-509. 3. Hombrouck A, et al. Antimicrob Agents Chemother. 2008 Jun;52(6):2069-78.
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