Cart
sales@molnova.com
Chelerythrine chloride
CAS No. 3895-92-9
Chelerythrine chloride( Broussonpapyrine chloride | NSC 646662 )
Catalog No. M14342 CAS No. 3895-92-9
Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 60 | In Stock |
|
| 2MG | 29 | In Stock |
|
| 5MG | 46 | In Stock |
|
| 10MG | 77 | In Stock |
|
| 25MG | 148 | In Stock |
|
| 50MG | 212 | In Stock |
|
| 100MG | 299 | In Stock |
|
| 200MG | 445 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameChelerythrine chloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionChelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK.
-
DescriptionChelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL; inhibits LPS-induced TNF-α level and NO production in LPS-induced murine peritoneal macrophages through selective inhibition of p38 MAPK and ERK1/2 activation; triggers apoptosis via direct action on mitochondria.
-
In Vitro——
-
In Vivo——
-
SynonymsBroussonpapyrine chloride | NSC 646662
-
PathwayAngiogenesis
-
TargetBcl-2
-
RecptorPKC
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number3895-92-9
-
Formula Weight383.8249
-
Molecular FormulaC21H18ClNO4
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 3.9 mg/mL
-
SMILESC[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
-
Chemical Name1,2-Dimethoxy-12-methyl[1,3]benzodi oxolo[5,6-c]phenanthridinium chloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chan SL, et al. J Biol Chem. 2003 Jun 6;278(23):20453-6.
2. Li W, et al. Inflammation. 2012 Dec;35(6):1814-24.
3. Wan KF, et al. J Biol Chem. 2008 Mar 28;283(13):8423-33.
4. Zhang YH, et al. J Mol Biol. 2006 Dec 1;364(3):536-49.
molnova catalog
related products
-
A09-003
A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.
-
MSN-125
MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM.
-
ML311
ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
