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ML311

CAS No. 315698-17-0

ML311( —— )

Catalog No. M19904 CAS No. 315698-17-0

ML311 is a selective inhibitor of the Mcl-1/Bim interaction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML311
  • Note
    Research use only, not for human use.
  • Brief Description
    ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
  • Description
    ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
  • In Vitro
    ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Mcl-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    315698-17-0
  • Formula Weight
    415.45
  • Molecular Formula
    C23H24F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 20 mg/mL;Water: Insoluble;Ethanol: 20 mg/mL
  • SMILES
    CCN1CCN(CC1)C(c1ccc(cc1)C(F)(F)F)c1ccc2cccnc2c1O
  • Chemical Name
    7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bannister T et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Biotechnology Information (US); 2010-2012 Apr 16.
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