BVT-14225( BVT14225 | BVT 14225 )

Catalog No. M14298 CAS No. 376638-65-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BVT-14225
Note

Research use only, not for human use.
Brief Description

A selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM.
Description

A selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM; displays >200-fold selectivity over human and murine 11β-HSD2. reduces glucose levels in diabetic KKA(y) mice.Diabetes Preclinical.
In Vitro

Selective inhibition of 11β-HSD1 decreases blood glucose concentrations in hyperglycaemic mice. Selective inhibitors of 11β-HSD1 have considerable potential as treatments for a number of diseases of great unmet medical need such as type 2 diabetes, obesity and metabolic syndrome, a multifactorial disorder. BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC50 for 11β-HSD1 on a human enzyme assay of 52 nM.
In Vivo

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Synonyms

BVT14225 | BVT 14225
Pathway

Metabolic Enzyme/Protease
Target

11β-HSD
Recptor

11β-HSD1
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

376638-65-2
Formula Weight

401.9313
Molecular Formula

C16H20ClN3O3S2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 27 mg/mL
SMILES

O=C(N(CC)CC)CC1=CSC(NS(=O)(C2=CC=CC(Cl)=C2C)=O)=N1
Chemical Name

4-Thiazoleacetamide, 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-

1. Barf T, et al. J Med Chem. 2002 Aug 29;45(18):3813-5. 2. Vicker N, et al. J Steroid Biochem Mol Biol. 2007 May;104(3-5):123-9.

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