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BVT-14225
CAS No. 376638-65-2
BVT-14225( BVT14225 | BVT 14225 )
Catalog No. M14298 CAS No. 376638-65-2
A selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 102 | In Stock |
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| 2MG | 51 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 138 | In Stock |
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| 25MG | 254 | In Stock |
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| 50MG | 403 | In Stock |
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| 100MG | 597 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBVT-14225
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NoteResearch use only, not for human use.
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Brief DescriptionA selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM.
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DescriptionA selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM; displays >200-fold selectivity over human and murine 11β-HSD2. reduces glucose levels in diabetic KKA(y) mice.Diabetes Preclinical.
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In VitroSelective inhibition of 11β-HSD1 decreases blood glucose concentrations in hyperglycaemic mice. Selective inhibitors of 11β-HSD1 have considerable potential as treatments for a number of diseases of great unmet medical need such as type 2 diabetes, obesity and metabolic syndrome, a multifactorial disorder. BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC50 for 11β-HSD1 on a human enzyme assay of 52 nM.
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In Vivo——
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SynonymsBVT14225 | BVT 14225
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PathwayMetabolic Enzyme/Protease
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Target11β-HSD
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Recptor11β-HSD1
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number376638-65-2
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Formula Weight401.9313
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Molecular FormulaC16H20ClN3O3S2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 27 mg/mL
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SMILESO=C(N(CC)CC)CC1=CSC(NS(=O)(C2=CC=CC(Cl)=C2C)=O)=N1
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Chemical Name4-Thiazoleacetamide, 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barf T, et al. J Med Chem. 2002 Aug 29;45(18):3813-5.
2. Vicker N, et al. J Steroid Biochem Mol Biol. 2007 May;104(3-5):123-9.
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