Cart
sales@molnova.com
Home - Products - Endocrinology/Hormones - Opioid Receptor - SB-612111 hydrochloride

SB-612111 hydrochloride

CAS No. 371980-94-8

SB-612111 hydrochloride( SB 612111 | SB612111 )

Catalog No. M14285 CAS No. 371980-94-8

A potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1503 Get Quote
50MG 3042 Get Quote
100MG 4140 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SB-612111 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM.
  • Description
    A potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM; displays good selectivity versus mu-(174-fold), delta-(6391-fold), and kappa (486-fold)-opioid receptors; antagonizes the antimorphine action of nociceptin (ED50= 0.69 mg/kg) with no measurable antinociceptive effects in vivo; antagonizes nociceptin-induced thermal hyperalgesia (ED50=0.62 mg/kg i.v.) in rat carrageenan inflammatory pain model.
  • In Vitro
    ——
  • In Vivo
    rel-SB-612111 hydrochloride (intravenous?injection; 0.6-10 nmol/mouse)antagonize nociceptin-induced thermal hyperalgesia in a dose-dependent manner with an ED50 of 0.62 mg/kg.rel-SB-612111 hydrochloride (intravenous?injection; 0.1-5 mg/kg) causes a significant inhibition of the carrageenan-induced reduction in paw withdrawal latencies in rat, however, untreated paw are uneffected. Animal Model:Male rats Dosage:0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 5 mg/kg Administration:Intravenous?injection; single dose Result:Had antihyperalgesic effects on carrageenan-induced rat paw.
  • Synonyms
    SB 612111 | SB612111
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    Opioid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    371980-94-8
  • Formula Weight
    454.86
  • Molecular Formula
    C24H29Cl2NO.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C2CCC(CC(C2=CC=C1)O)CN3CCC(CC3)C4=C(C=CC=C4Cl)Cl.Cl
  • Chemical Name
    7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liao YY, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):84-8. 2. Spagnolo B, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):961-7. 3. Rizzi A, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):968-74. 4. Zaratin PF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):454-61.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Ac-RYYRIK-NH2

    High affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.

  • [Nphe1]Nociceptin(1-...

    Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.

  • Trimebutine CTB salt

    Trimebutine CTB salt (GIC-1001) is an opioid receptor agonist used in the study of pain.

Sign In Join Free