Diazoxide

Research use only, not for human use.

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions.

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions.(In Vitro):Diazoxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia.Diazoxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage. (In Vivo):Diazoxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels.Treatment with Diazoxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg.

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NSC 64198 | NSC 76130 | SRG 95213

Endocrinology/Hormones

ATPase

Na+/K+-ATPase| Potassium Channel

Cardiovascular Disease

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364-98-7

230.67

C8H7ClN2O2S

>98% (HPLC)

Soluble in DMSO

CC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2

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(-20℃)

With Ice Pack

≥ 2 years