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N.41
CAS No. 357441-99-7
N.41( HIV inhibitor N.41 | Vif inhibitor N.41 )
Catalog No. M14228 CAS No. 357441-99-7
N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameN.41
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NoteResearch use only, not for human use.
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Brief DescriptionN.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).
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DescriptionN.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM); shows potent antiviral activity in A3G(+) but not in A3G(-) T cells with IC50 of 8.4 uM and TC50 of >100 uM against HIV-1Ba-L replication in peripheral blood mononuclear cells; inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner.
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In Vitro——
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In Vivo——
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SynonymsHIV inhibitor N.41 | Vif inhibitor N.41
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research Area——
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Indication——
Chemical Information
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CAS Number357441-99-7
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Formula Weight254.289
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Molecular FormulaC15H14N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC/C(NC1=CC=C(O)C=C1)=C/C(C2=CC=CN=C2)=O
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Chemical Name3-((4-hydroxyphenyl)amino)-1-(pyridin-3-yl)but-2-en-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pery E, et al. J Biol Chem. 2015 Apr 17;290(16):10504-17.
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