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Celastrol
CAS No. 34157-83-0
Celastrol( Tripterin )
Catalog No. M14158 CAS No. 34157-83-0
Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 90 | In Stock |
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| 50MG | 113 | In Stock |
|
| 100MG | 154 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCelastrol
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NoteResearch use only, not for human use.
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Brief DescriptionCelastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine.
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DescriptionCelastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5 uM; also inhibits 26S proteasome in intact androgen-independent PC-3 and androgen-dependent LNCaP prostate cancer cells at 1-5 uM, induces apoptotic cell death, and accumulates ubiquitinated proteins and natural proteasome substrates, IκB-α, Bax, and p27, and/or suppression of AR protein expression; promotes significant tumor growth inhibition and massive apoptosis induction in vivo.
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In Vitro——
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In Vivo——
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SynonymsTripterin
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PathwayProteasome/Ubiquitin
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TargetProteasome
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Recptor20Sproteasome
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number34157-83-0
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Formula Weight450.6096
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Molecular FormulaC29H38O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
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Chemical Name24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, (9.beta.,13.alpha.,14.beta.,20.alpha.)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yang H, et al. Cancer Res. 2006 May 1;66(9):4758-65.
2. Yadav VR, et al. J Mol Med (Berl). 2010 Dec;88(12):1243-53.
3. Chen M, et al. Mol Cancer Res. 2009 Dec;7(12):1946-53.
4. Ge P, et al. Neurol Res. 2010 Feb;32(1):94-100.
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