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Capzimin
CAS No. 2084867-65-0
Capzimin( Rpn11 inhibitor 3027 )
Catalog No. M13248 CAS No. 2084867-65-0
Capzimin (Rpn11 inhibitor 3027) is a derivative of 8TQ, and potent and specific inhibitor of proteasome isopeptidase Rpn11 with IC50 of 0.34 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCapzimin
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NoteResearch use only, not for human use.
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Brief DescriptionCapzimin (Rpn11 inhibitor 3027) is a derivative of 8TQ, and potent and specific inhibitor of proteasome isopeptidase Rpn11 with IC50 of 0.34 uM.
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DescriptionCapzimin (Rpn11 inhibitor 3027) is a derivative of 8TQ, and potent and specific inhibitor of proteasome isopeptidase Rpn11 with IC50 of 0.34 uM, >7-fold improved potency over 8TQ (quinoline-8-thiol); shows >5-fold selectivity for Rpn11 over the related JAMM proteases and >2 logs less activity towards metalloenzymes (HDAC6, MMP2, MMP12, and carbonic anhydrase II); stabilizes proteasome substrates, induced an unfolded protein response, and blocks proliferation of cancer cells (HCT116 GI50=2.0 uM), including bortezomib-resistant retinal pigment epithelial cells.
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In Vitro——
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In Vivo——
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SynonymsRpn11 inhibitor 3027
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PathwayProteasome/Ubiquitin
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TargetProteasome
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RecptorProteasome
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2084867-65-0
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Formula Weight315.409
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Molecular FormulaC15H13N3OS2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=CC2=CC=CC(S)=C2N=C1)NCCC3=NC=CS3
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Chemical Name8-Mercapto-N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li J, et al. Nat Chem Biol. 2017 May;13(5):486-493.
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