CK-0106023( CK 0106023 | CK0106023 )

Catalog No. M14141 CAS No. 336115-72-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CK-0106023
Note

Research use only, not for human use.
Brief Description

A potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.
Description

A potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM; displays >200-fold selectivity over the mitotic kinesins CENP-E, MKLP1 and Kif1A; causes mitotic arrest and growth inhibition in several human tumor cell lines; exhibits antitumor activity in tumor-bearing mice.
In Vitro

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In Vivo

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Synonyms

CK 0106023 | CK0106023
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Kinesin
Recptor

Kinesin
Research Area

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Indication

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CAS Number

336115-72-1
Formula Weight

595.96
Molecular Formula

C30H32BrClN4O2
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(N(C(C(N1CC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC)CCCN(C)C)C4=CC=C(Br)C=C4
Chemical Name

N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide

1. Sakowicz R, et al. Cancer Res. 2004 May 1;64(9):3276-80. 2. Zhang B, et al. Anal Biochem. 2005 Oct 15;345(2):326-35.

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