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CK-0106023
CAS No. 336115-72-1
CK-0106023( CK 0106023 | CK0106023 )
Catalog No. M14141 CAS No. 336115-72-1
A potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCK-0106023
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.
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DescriptionA potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM; displays >200-fold selectivity over the mitotic kinesins CENP-E, MKLP1 and Kif1A; causes mitotic arrest and growth inhibition in several human tumor cell lines; exhibits antitumor activity in tumor-bearing mice.
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In Vitro——
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In Vivo——
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SynonymsCK 0106023 | CK0106023
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetKinesin
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RecptorKinesin
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Research Area——
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Indication——
Chemical Information
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CAS Number336115-72-1
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Formula Weight595.96
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Molecular FormulaC30H32BrClN4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N(C(C(N1CC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC)CCCN(C)C)C4=CC=C(Br)C=C4
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Chemical NameN-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sakowicz R, et al. Cancer Res. 2004 May 1;64(9):3276-80.
2. Zhang B, et al. Anal Biochem. 2005 Oct 15;345(2):326-35.
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