ζ-Stat

Research use only, not for human use.

ζ-Stat (1,3,6-Naphthalenetrisulfonic acid) is a novel PKC-zeta (PKC-ζ) specific inhibitor with IC50 of 5 uM.

ζ-Stat (1,3,6-Naphthalenetrisulfonic acid) is a novel PKC-zeta (PKC-ζ) specific inhibitor with IC50 of 5 uM, showed only 13% inhibition on PKC-I at 20 uM; downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis, significantly decreases melanoma cell proliferation of SK-MEL-2 and MeWo.

:Cell Proliferation Assay Cell Line:MEL-F-NEO, SK-MEL-2 and MeWo cellsConcentration:0.1, 0.5, 1, 2.5, 5, 7.5, 10 μM Incubation Time:3 days Result:Decreased proliferation by 47.7% for 5 μM in SK-MEL-2 cells and by 50.6% for 5 μM in MeWo cells.Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM.Western Blot Analysis Cell Line:SK-MEL-2 and MeWo cells Concentration:5 μM Incubation Time:3 days Result:Decreased phosphorylated and total PKC-ζ levels.

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NSC37044

Angiogenesis

PKC

PKC

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3316-02-7

384.344

C10H8O10S3

>98% (HPLC)

In Vitro:?H2O : 62.5 mg/mL (162.61 mM)

C1=C2C=C(C=C(C2=C(C=C1S(=O)(=O)O)O)S(=O)(=O)O)S(=O)(=O)O

8-hydroxy-1,3,6-naphthalenetrisulfonic acid

(-20℃)

With Ice Pack

≥ 2 years